A series opener between the Cleveland Guardians (2-4) and Los Angeles Angels (4-2) is scheduled for Friday at 9:38 p.m. ET, at Angel Stadium.

The Guardians are a tight favorite (-116 moneyline odds) when they take the field against the Angels (-104). The Cleveland Guardians will give the start to Gavin Williams and the Angels will counter with Jose Soriano (1-0, 0.00 ERA).

The Guardians’ matchup Wednesday versus the Padres resulted in a 5-2 loss. Carlos Santana went 2-for-3 in the defeat, while Ben Lively threw 4 1/3 innings, giving up four earned runs on seven hits while striking out four en route to taking the loss.

The Angels lost to the Cardinals Wednesday, with Ian Anderson getting the loss while throwing one inning, giving up four earned runs on six hits while striking out one. Logan O’Hoppe went 1-for-4 with a home run and four RBI to pace the Angels’ offense.

Before the Guardians vs. Angels matchup, here is what you need to prepare for Friday’s baseball action, including viewing options.

Cleveland Guardians vs. Los Angeles Angels odds, line and spread

MLB odds courtesy of BetMGM Sportsbook. Odds updated Friday at 9:16 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

• Favorite: Guardians (-116, bet $116 to win $100)
• Underdog: Angels (-104, bet $104 to win $100)
• Over/under: 8

Guardians vs. Angels: Game time and live stream info

• Game day: Friday, April 4, 2025
• Game time: 9:38 p.m. ET
• Location: Anaheim, California
• Stadium: Angel Stadium
• TV channel: FDSW and CLEG
• Live stream: Watch LIVE with Fubo! (Regional restrictions may apply)

Watch Guardians vs. Angels on Fubo!Guardians stats and trends

Guardians betting records

• The Guardians have not played a game this season while listed as the favorite.
• Cleveland has not entered a game this season with shorter moneyline odds than -116.
• The Guardians have a 53.7% chance to win this game based on the implied probability of the moneyline.
• Games involving Cleveland have gone over the total set by bookmakers in three of six chances this season.
• The Guardians have an ATS record of 2-4-0 in six games with a spread this season.

Gavin Williams (Guardians probable starter)

• Williams (0-0) pitches for the Guardians to make his second start of the season.
• His most recent appearance was on Saturday against the Kansas City Royals, when the righty tossed five innings, surrendering two earned runs while giving up four hits.
• In one appearance this season, he has a 3.60 ERA and 3.6 strikeouts per nine innings, while opponents are hitting .222 against him.
• The opposing Angels offense has the 25th-ranked slugging percentage (.310) and is 25th in MLB play with four home runs. It has a collective .198 batting average, and is 29th in MLB with 39 total hits and 19th in MLB action scoring 24 runs.

Guardians batting stats

• The Guardians’ seven home runs rank 16th in Major League Baseball.
• Fueled by 17 extra-base hits, Cleveland ranks 14th in MLB with a .392 slugging percentage this season.
• The Guardians have a team batting average of .227 this season, which ranks 15th among MLB teams.
• Cleveland has scored 20 runs (just 3.3 per game) this season, which ranks 26th in MLB.
• The Guardians have an OBP of .295 this season, which ranks 16th in MLB.
• Cleveland has shown patience at the plate this season with the sixth-best rate of strikeouts per game (8.2) among MLB offenses.

Angels stats and trends

Angels betting records

• The Angels have been victorious in two of the three contests they have been chosen as underdogs in this season.
• This season, Los Angeles has been victorious two times in three chances when named as an underdog of at least -104 or longer on the moneyline.
• The Angels have an implied victory probability of 51% according to the moneyline set for this matchup.
• Los Angeles’ games have gone over the total in four of its six opportunities.
• The Angels are 2-4-0 against the spread in their six games that had a posted line this season.

José Soriano (Angels probable starter)

• Soriano (1-0) gets the starting nod for the Angels, his second this season.
• In his last appearance on Saturday, the right-hander tossed seven scoreless innings against the Chicago White Sox while surrendering two hits.
• In his one game this season, opposing hitters have compiled a batting average of only .095 against him. He has a 0.00 ERA and averages 6.4 strikeouts per nine innings.
• The opposing Guardians offense has the 14th-ranked slugging percentage (.392) and ranks 16th in home runs hit (seven) in all of MLB. They have a collective .227 batting average, and are 21st in the league with 44 total hits and 26th in MLB play scoring 20 runs.
• Among qualifying pitchers in MLB play this season, the 26-year-old ranks first in ERA (0.00), fifth in WHIP (.571), and 54th in K/9 (6.4).

Angels batting stats

• The Angels average 0.7 home runs per game to rank 25th in MLB action with four total home runs.
• This season, Los Angeles is 25th in the majors with a .310 slugging percentage.
• The Angels rank 23rd in the majors with a .198 batting average.
• Averaging 4.0 runs per game (24 total), Los Angeles is the 19th-highest scoring team in the majors.
• The Angels are 26th in MLB with a .267 on-base percentage.

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